Santo Spirito

Coordinates: 43°19′9.003″N 11°20′14.552″E / 43.3191675°N 11.33737556°E / 43.3191675; 11.33737556

Santo Spirito is a church in Siena, Tuscany, Italy. The current edifice is largely a reconstruction from 1498-1504.

It has a notable Renaissance portal by Baldassarre Peruzzi, while the interior houses numerous artworks. These include works by Il Sodoma in the Spaniards Chapel, a canvas with the Miracle of St. Hyacinth by Francesco Vanni in the right transept surrounded by frescoes of Ventura Salimbeni, a rare terracotta nativity scene by Ambrogio della Robbia, Four Saints by Rutilio Manetti (pilasters flanking the high altar) and, in the apse, a Pentecost by Giuseppe Nicola Nasini.

In the sacristy, located where once was the cloister, is a 1516 fresco by Fra Paolo da Pistoia.